Beyond testosterone cypionate: evidence behind the use of nandrolone in male health and wellness

Nandrolone, or 19-nortestosterone, is a unique androgen and anabolic steroid which is used in the form of injectable ester prodrugs like nandrolone decanoate. It is closely related to testosterone structurally but has a number of important pharmacological differences in comparison. These differences include inactivation by 5α-reductase rather than potentiation, less or no conversion into estradiol, and much greater progestogenic activity.

At the base of the article each reference will be linked to a peer-reviewed study or paper. All Steroidal.com content is medically reviewed and fact checked to ensure as much factual accuracy as possible. If you think there has been an overdose, call your poison control center or get medical care right away. The anabolic effect on proteins requires a specific diet necessary to maintain a correct nitrogen balance.

• First approved in 1992 in the treatment of benign prostatic hypertrophy, finasteride was approved for the treatment of alopecia in 1997 at a dose of 1 mg daily (propecia®) (24).
• The affinity of nandrolone for the PR is 5- to 20-fold higher than that of testosterone and its progestogenic potency is correspondingly improved (Wiki; Wiki; Bardin & Janne, 1986).
• Administering a dopamine agonist (Cabergoline) will help reduce the risk of gynecomastia by lowering aggravating hormones like prolactin.
• Surgically induced anephric patients have been reported to be less responsive.
• However, the situation dramatically changed after the introduction of the Anabolic Steroid Control Act in 1990, and subsequently reinforced by the Anabolic Steroid Control Act of 2004.
• Due to the decrease in FSH levels, the growth and development of Sertoli cells is insufficient 56.

Nandrolone and joint healing

It’s not as exciting as a steroid like Dianbol that packs on size and strength seemingly in days or that provides the overall impact of excitement such as a steroid like Trenbolone. But in terms of an all around steroid, one that produces quality gains, promotes so many health benefits and produces solid results, Nandrolone will always be at the top of the list. While quality Nandrolone isn’t hard to find the primary issue of concern is and will always be legality. Nandrolone is classified as a Schedule III controlled substance by way of the Steroid Control Act of 1990. Any purchase or possession of a Schedule III drug is not legal without a prescription. An online purchase will not be a legal purchase and can come with heavy legal consequences.

Cancer of the breast/prostate

Call your doctor or get medical help if you have any side effects that bother you or do not go away. Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take nandrolone with all of your drugs and health problems.

This can sometimes interact with mammary glands, hence it https://affittacameresalento.com/anastrozole-understanding-its-uses-and-benefits/ can result in gynecomastia, but typically only in individuals that are particularly sensitive to these side effects. But aside from the gym rats, a lot of medical professionals acknowledge how great Nandrolone is as well. They can appreciate its positive effects, and for that, they have adapted the drug throughout time for its benefits. It’s really great for muscle wasting syndromes, and it can help with fatigue and weakness found in older patients. It’s also awesome with dealing with anemia, and nandrolone has been found to even eliminate some forms of brain cancer, and for burn victims especially, it might as well be a miracle drug.

Such effects and reversibility are dependent on dosage and treatment duration 30,42,43. For transmasculine people who want the benefits of nandrolone except the lesser facial hair growth, topical testosterone to the beard area can potentially be used in conjunction with nandrolone injections to restore full facial hair growth. 5α-Reductase inhibitors have similar effects relative to the profile of 5α-reductase type 2 deficiency. For this reason, they are used in the treatment and prevention of scalp hair loss in men and off-label for hirsutism (excessive facial/body hair growth) in women. Low-quality evidence suggests that finasteride has similar effectiveness to antiandrogens like spironolactone and flutamide in the treatment of hirsutism in women (Barrionuevo et al., 2018; van Zuuren et al., 2015).

As transfeminine people also have prostate glands, the weak effects of nandrolone in the prostate are potentially of relevance to us as well. However, due to estrogen therapy and androgen deprivation, the prostate is atrophied in transfeminine people and prostate cancer is very rare (Wiki). In relation to this, the favorable prostate profile of nandrolone may be of little significance for transfeminine people.